Peptide Drugs are potential therapeutic agent used against several disease attributing to its features high activity, target specificity, low toxicity, and minimal non-specific or drug–drug interactions. The low physicochemical properties such as poor membrane permeability and low target specific action when administered orally demands for improved peptide drug. Glycosylation of peptides is a promising strategy to modulate the physicochemical properties of peptide drugs and for penetration of peptides across biological membranes.
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New product launches by the key manufacturers are fueling growth of the glycosylated peptide market. For instance, in 2017, Pfizer Inc., received the U.S. Food and Drug Administration (FDA) approval for Ixifi (infliximab-qbtx), a chimeric human-murine monoclonal antibody, as a treatment for patients with rheumatoid arthritis, Crohn’s disease, pediatric Crohn’s disease, ulcerative colitis, ankylosing spondylitis, psoriatic arthritis, and plaque psoriasis. Furthermore, in Feb 2017, CT-P10 received approval from the European Commission and in June 2017, it was approved by U.S. FDA.
Moreover, market players involved in the glycosylated peptide market are adopting strategies such as merger and acquisition for expanding geographical coverage or product portfolio. For instance, in 2014, Bachem AG, a peptide manufacturer and GlyTech Inc., a glycosylated drug developer, entered into co-promotional agreement for GlyTech’s glycosylation technology. The agreement will leverage Bachem by enhancing its sales and marketing resources and GlyTech to promote Bachem for manufacturing of its glycopeptides and glycoproteins.
Increasing application of glycosylated peptide is expected to fuel growth of the glycosylated peptide market. For instance, in 2015, Sussex Research Laboratories Inc., a specialist in glycodesign and the synthesis of complex carbohydrates, announced successful clinical trials for Glycolastin, anti-aging glycopeptide cosmetic active.
The in-vitro studies for comparing efficacy of Glycolastin against non-glycosylated peptide reported increased secretion of structural protein elastin, fibronectin, and collagens by fibroblast. Furthermore, company plans to commercialize Glycolastin, as a cosmetic active in topical anti-aging products.
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Major players operating in glycosylated peptide market include Pfizer Inc., Teva Pharmaceutical Industries Ltd., Bachem Holding AG, GlyTech, Inc., Sussex Research Laboratories Inc., Samsung Bioepis, and Celltrion Inc.
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